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bmp4 treatment (R&D Systems)

Name: bmp4 treatment
Brand: R&D Systems
Rating: 94 (236 reviews)

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R&D Systems bmp4 treatment
Bmp4 Treatment, supplied by R&D Systems, used in various techniques. Bioz Stars score: 94/100, based on 236 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/bmp4 treatment/product/R&D Systems
Average 94 stars, based on 236 article reviews

bmp4 treatment - by Bioz Stars, 2026-03

94/100 stars

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Metformin inhibits HO formation in Nse-Bmp4 mice. A. Schematic of the study design, highlighting the systematic process of target tissue collection at specified time intervals for microCT analysis. B. Representative microCT images from uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment. C. Statistical analysis of the HO volume in uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). D. Visual representation of our study design, highlighting the systematic process of collecting target tissue at specific time intervals for microCT analysis. E. Representative microCT images from uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment. F. Statistical analysis of the HO volume in uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Journal: American Journal of Translational Research

Article Title: Metformin alleviates genetic and traumatic heterotopic ossification by inhibiting infiltration and mitochondrial metabolism of myeloid cells

doi:

Figure Lengend Snippet: Metformin inhibits HO formation in Nse-Bmp4 mice. A. Schematic of the study design, highlighting the systematic process of target tissue collection at specified time intervals for microCT analysis. B. Representative microCT images from uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment. C. Statistical analysis of the HO volume in uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). D. Visual representation of our study design, highlighting the systematic process of collecting target tissue at specific time intervals for microCT analysis. E. Representative microCT images from uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment. F. Statistical analysis of the HO volume in uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Article Snippet: Metformin treatment Nse-Bmp4 mice, after receiving the tibial muscle injury, were treated with metformin (HY-B0627, 0.2 g/300 mL or 0.4 g/300 mL, MCE).

Techniques: Two Tailed Test

Metformin inhibits HO formation in Tie2-cre; Acvr1R206H/+ mice. A. Visual representation of our study design, highlighting the systematic process of collecting target tissue at specific time intervals for microCT analysis. B. Representative microCT images from uninjured Tie2-cre; Acvr1R206H/+ mice and injured Tie2-cre; Acvr1R206H/+ mice receiving either water or metformin treatment. C. Statistical analysis of the HO volume in uninjured Tie2-cre; Acvr1R206H/+ mice and injured Tie2-cre; Acvr1R206H/+ mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). D. Visual representation of our study design, highlighting the systematic process of collecting target tissue at specific time intervals for microCT analysis. E. Representative microCT images from uninjured Tie2-cre; Acvr1R206H/+ mice and injured Tie2-cre; Acvr1R206H/+ mice receiving either water or metformin treatment. F. Statistical analysis of the HO volume in uninjured Tie2-cre; Acvr1R206H/+ mice and injured Tie2-cre; Acvr1R206H/+ mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Journal: American Journal of Translational Research

Article Title: Metformin alleviates genetic and traumatic heterotopic ossification by inhibiting infiltration and mitochondrial metabolism of myeloid cells

doi:

Figure Lengend Snippet: Metformin inhibits HO formation in Tie2-cre; Acvr1R206H/+ mice. A. Visual representation of our study design, highlighting the systematic process of collecting target tissue at specific time intervals for microCT analysis. B. Representative microCT images from uninjured Tie2-cre; Acvr1R206H/+ mice and injured Tie2-cre; Acvr1R206H/+ mice receiving either water or metformin treatment. C. Statistical analysis of the HO volume in uninjured Tie2-cre; Acvr1R206H/+ mice and injured Tie2-cre; Acvr1R206H/+ mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). D. Visual representation of our study design, highlighting the systematic process of collecting target tissue at specific time intervals for microCT analysis. E. Representative microCT images from uninjured Tie2-cre; Acvr1R206H/+ mice and injured Tie2-cre; Acvr1R206H/+ mice receiving either water or metformin treatment. F. Statistical analysis of the HO volume in uninjured Tie2-cre; Acvr1R206H/+ mice and injured Tie2-cre; Acvr1R206H/+ mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Article Snippet: Metformin treatment Nse-Bmp4 mice, after receiving the tibial muscle injury, were treated with metformin (HY-B0627, 0.2 g/300 mL or 0.4 g/300 mL, MCE).

Techniques: Two Tailed Test

Metformin inhibits HO formation in tenotomy-induced HO model mice. A. Visual representation of our study design, highlighting the systematic process of collecting target tissue at specific time intervals for microCT analysis. B. Representative microCT images from uninjured mice and tenotomy mice receiving either water or metformin treatment. C. Statistical analysis of the HO volume in uninjured mice and tenotomy mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). D. Visual representation of our study design, highlighting the systematic process of collecting target tissue at specific time intervals for microCT analysis. E. Representative microCT images from uninjured mice and tenotomy mice receiving either water or metformin treatment. F. Statistical analysis of the HO volume in uninjured mice and tenotomy mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Journal: American Journal of Translational Research

Article Title: Metformin alleviates genetic and traumatic heterotopic ossification by inhibiting infiltration and mitochondrial metabolism of myeloid cells

doi:

Figure Lengend Snippet: Metformin inhibits HO formation in tenotomy-induced HO model mice. A. Visual representation of our study design, highlighting the systematic process of collecting target tissue at specific time intervals for microCT analysis. B. Representative microCT images from uninjured mice and tenotomy mice receiving either water or metformin treatment. C. Statistical analysis of the HO volume in uninjured mice and tenotomy mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). D. Visual representation of our study design, highlighting the systematic process of collecting target tissue at specific time intervals for microCT analysis. E. Representative microCT images from uninjured mice and tenotomy mice receiving either water or metformin treatment. F. Statistical analysis of the HO volume in uninjured mice and tenotomy mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Article Snippet: Metformin treatment Nse-Bmp4 mice, after receiving the tibial muscle injury, were treated with metformin (HY-B0627, 0.2 g/300 mL or 0.4 g/300 mL, MCE).

Techniques: Two Tailed Test

Metformin inhibits the infiltration of myeloid cells in BMP4-dependent HO model mice. A. Representative flow cytometry analysis of myeloid cells in uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment. B. Statistical analysis of the myeloid cell frequency in uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). C, D. Representative flow cytometry analysis of myeloid cells in uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment. E, F. Statistical analysis of the neutrophil and monocyte frequencies in uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Journal: American Journal of Translational Research

Article Title: Metformin alleviates genetic and traumatic heterotopic ossification by inhibiting infiltration and mitochondrial metabolism of myeloid cells

doi:

Figure Lengend Snippet: Metformin inhibits the infiltration of myeloid cells in BMP4-dependent HO model mice. A. Representative flow cytometry analysis of myeloid cells in uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment. B. Statistical analysis of the myeloid cell frequency in uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). C, D. Representative flow cytometry analysis of myeloid cells in uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment. E, F. Statistical analysis of the neutrophil and monocyte frequencies in uninjured Nse-Bmp4 mice and injured Nse-Bmp4 mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Article Snippet: Metformin treatment Nse-Bmp4 mice, after receiving the tibial muscle injury, were treated with metformin (HY-B0627, 0.2 g/300 mL or 0.4 g/300 mL, MCE).

Techniques: Flow Cytometry, Two Tailed Test

Metformin inhibits the infiltration of myeloid cells in FOP modeled mice. A. Representative flow cytometry analysis of myeloid cells in uninjured FOP model mice and injured FOP model mice receiving either water or metformin treatment. B. Statistical analysis of the myeloid cell frequency in uninjured FOP model mice and injured FOP model mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). C, D. Representative flow cytometry analysis of myeloid cells in uninjured FOP model mice and injured FOP model mice receiving either water or metformin treatment. E, F. Statistical analysis of neutrophil and monocyte frequencies in uninjured FOP model mice and injured FOP modeled mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Journal: American Journal of Translational Research

Article Title: Metformin alleviates genetic and traumatic heterotopic ossification by inhibiting infiltration and mitochondrial metabolism of myeloid cells

doi:

Figure Lengend Snippet: Metformin inhibits the infiltration of myeloid cells in FOP modeled mice. A. Representative flow cytometry analysis of myeloid cells in uninjured FOP model mice and injured FOP model mice receiving either water or metformin treatment. B. Statistical analysis of the myeloid cell frequency in uninjured FOP model mice and injured FOP model mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). C, D. Representative flow cytometry analysis of myeloid cells in uninjured FOP model mice and injured FOP model mice receiving either water or metformin treatment. E, F. Statistical analysis of neutrophil and monocyte frequencies in uninjured FOP model mice and injured FOP modeled mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Article Snippet: Metformin treatment Nse-Bmp4 mice, after receiving the tibial muscle injury, were treated with metformin (HY-B0627, 0.2 g/300 mL or 0.4 g/300 mL, MCE).

Techniques: Flow Cytometry, Two Tailed Test

Metformin inhibits the infiltration of myeloid cells in traumatic HO modeled mice. A. Representative flow cytometry analysis of myeloid cells in uninjured WT mice and WT tenotomy mice receiving either water or metformin treatment. B. Statistical analysis of the myeloid cell frequency in uninjured WT mice and WT tenotomy mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). C, D. Representative flow cytometry analysis of myeloid cells in uninjured WT mice and WT tenotomy mice receiving either water or metformin treatment. E, F. Statistical analysis of neutrophil and monocyte frequencies in uninjured WT mice and WT tenotomy mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Journal: American Journal of Translational Research

Article Title: Metformin alleviates genetic and traumatic heterotopic ossification by inhibiting infiltration and mitochondrial metabolism of myeloid cells

doi:

Figure Lengend Snippet: Metformin inhibits the infiltration of myeloid cells in traumatic HO modeled mice. A. Representative flow cytometry analysis of myeloid cells in uninjured WT mice and WT tenotomy mice receiving either water or metformin treatment. B. Statistical analysis of the myeloid cell frequency in uninjured WT mice and WT tenotomy mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). C, D. Representative flow cytometry analysis of myeloid cells in uninjured WT mice and WT tenotomy mice receiving either water or metformin treatment. E, F. Statistical analysis of neutrophil and monocyte frequencies in uninjured WT mice and WT tenotomy mice receiving either water or metformin treatment (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Article Snippet: Metformin treatment Nse-Bmp4 mice, after receiving the tibial muscle injury, were treated with metformin (HY-B0627, 0.2 g/300 mL or 0.4 g/300 mL, MCE).

Techniques: Flow Cytometry, Two Tailed Test

Metformin inhibits the activity of complex I and mitochondrial metabolism in three HO model mice. (A-C) Statistical analysis of complex I activity in myeloid cells from BMP4-dependent HO model mice (A), FOP model mice (B), and traumatic HO model (C) mice (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). (D-F) Statistical analysis of mitochondrial mass in myeloid cells from BMP4-dependent HO model mice (D), FOP model mice (E), and traumatic HO model (F) mice (n=5 per group). Data are presented as mean ± SD of biological replicates. n.s. indicates no significance (unpaired two-tailed t-test). (G-I) Statistical analysis of ROS production in myeloid cells from BMP4-dependent HO model mice (G), FOP model mice (H), and traumatic HO model (I) mice (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). (J-L) Statistical analysis of MMP in myeloid cells from BMP4-dependent HO model mice (J), FOP model mice (K), and traumatic HO model (L) mice (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Journal: American Journal of Translational Research

Article Title: Metformin alleviates genetic and traumatic heterotopic ossification by inhibiting infiltration and mitochondrial metabolism of myeloid cells

doi:

Figure Lengend Snippet: Metformin inhibits the activity of complex I and mitochondrial metabolism in three HO model mice. (A-C) Statistical analysis of complex I activity in myeloid cells from BMP4-dependent HO model mice (A), FOP model mice (B), and traumatic HO model (C) mice (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). (D-F) Statistical analysis of mitochondrial mass in myeloid cells from BMP4-dependent HO model mice (D), FOP model mice (E), and traumatic HO model (F) mice (n=5 per group). Data are presented as mean ± SD of biological replicates. n.s. indicates no significance (unpaired two-tailed t-test). (G-I) Statistical analysis of ROS production in myeloid cells from BMP4-dependent HO model mice (G), FOP model mice (H), and traumatic HO model (I) mice (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test). (J-L) Statistical analysis of MMP in myeloid cells from BMP4-dependent HO model mice (J), FOP model mice (K), and traumatic HO model (L) mice (n=5 per group). Data are presented as mean ± SD of biological replicates. *P < 0.05, **P < 0.01, ***P < 0.001 (unpaired two-tailed t-test).

Article Snippet: Metformin treatment Nse-Bmp4 mice, after receiving the tibial muscle injury, were treated with metformin (HY-B0627, 0.2 g/300 mL or 0.4 g/300 mL, MCE).

Techniques: Activity Assay, Two Tailed Test

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